Intestinal changes could explain rapid improvements in diabetes
Courtesy of Stylopoulos Laboratory
A beefed-up chunk of intestines might do the heavy lifting of gastric bypass surgery.
The surgery’s rapid diabetes-improving effects appear to stem from growth of new intestinal tissue. After having an operation to remodel the gut, obese rats build the new tissue by drawing sugar from the blood, researchers report in the July 26 Science. This energy drain could explain how the most popular type of gastric bypass lowers diabetic patients’ sugar levels surprisingly swiftly, says coauthor Nicholas Stylopoulos, an obesity researcher at Harvard Medical School.
It’s the first time researchers have linked the effects of gastric bypass surgery to the gut’s sugar use, says Blandine Laferrère, a clinical diabetes researcher at Columbia University. “It’s a fascinating new piece of the puzzle,” she says.
Currently, gastric bypass surgery is one of the best treatment options for morbid obesity and obesity-related diabetes