Map of Zika virus reveals how it shifts as it matures | Science News


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Map of Zika virus reveals how it shifts as it matures

New look at the immature virus could hint at how Zika becomes infectious

7:00am, January 31, 2017
cryo-electron microscopy map of immature zika virus

ZIKA PEEK Inside an immature Zika virus (interior shown at right), the protein and RNA core (dark blue) contacts the inner layer of the viral membrane (aqua, see arrows). A surface view (left) shows proteins that make up the exterior (red, yellow and green).

Before an immature Zika virus becomes infectious, it does some major remodeling.

In a fledgling virus particle, the inner protein and RNA core (shown in dark blue above, right) forms bridges to the membrane layer that surrounds it. As the virus matures, the core shuffles around and the bridges melt away (below, right).

It’s the first time scientists have seen such rearrangement in the core of a flavivirus, the group that also includes the viruses that cause dengue, West Nile and yellow fever, says virologist Richard Kuhn of Purdue University in West Lafayette, Ind.

Scientists don’t know why the immature Zika virus reshuffles its insides, Kuhn says — perhaps it helps the maturing virus become infectious. But that’s the next big question to answer, he says.

If blocking the reorganization somehow made mature viruses harmless, scientists would have a new clue about preventing Zika infection. Kuhn and colleagues’

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