First 3-D views show how drugs bind to cells
Proteins turned on by opium and similar substances in the body have now been caught in action. Two new snapshots show how cellular proteins lasso molecules in the opium family, revealing the 3-D structure of such pairings for the first time.
The work represents a major step toward designing more specific analgesics and other drugs that lack opioids’ nasty side effects, two teams of researchers report online March 21 in Nature.
“Both are landmark studies,” says Gavril Pasternak, a neuroscientist who designs opioids at the Sloan-Kettering Institute in New York City, and who wasn’t involved in either study. “The