Amyloid-beta might spread in rare cases
Z. JAUNMUKTANE ET AL/NATURE 2015
Under rare conditions, an Alzheimer’s-related protein may have jumped between people, scientists reported this year (SN: 10/17/15, p. 12). If true, that observation, the first of its kind, could recast the way scientists view the disease. “This was a highly unusual finding,” says John Collinge of University College London.
Scientists already had hints that the protein in question, amyloid-beta, behaves like an infectious prion, a misshapen protein that coaxes other proteins to misfold and spread from cell to cell. In a study reported in Nature, Collinge and colleagues found A-beta buildup in four of eight postmortem brains from people who had received growth hormone injections