Tracking the activity of 11 genes linked with sepsis may lead to a quicker diagnosis for the condition.
Sepsis is a fast-acting, whole-body inflammatory response to infectious pathogens. It sickens more than 1 million people in the United States each year. But differentiating sepsis from noninfectious inflammation as a result of surgery or blunt force trauma is challenging. In a new study, scientists analyzed genetic data from 663 critically ill patients with inflammation from either sepsis or trauma and identified 11 genes that distinguished sepsis inflammation from the other type. The results appear May 13 in Science Translational Medicine.
Understanding the activity of those 11 genes and its link with sepsis could help doctors develop a blood test to diagnose the condition days sooner than current methods, the scientists say.