Changes in yeast cells help explain caloric restriction’s longevity boost
The cells have just as much energy available, so they are not really starving, says research leader Vladimir Titorenko, a molecular biologist at ConcordiaUniversity in Montreal, Canada.
“It’s not a starvation; it’s just a specific sort of remodeling of the cells’ metabolism in a way that also causes the organism to live longer,” Titorenko says.
Titorenko and his team fed yeast cells a limited diet that contained 30 to 50 percent fewer calories than normal but was still nutritionally complete. In response, the cells cut back on making lipids and instead reroute