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Body attacks lab-made stem cells

In mice, the immune system targets and destroys reprogrammed adult skin cells

1:15pm, May 13, 2011

Stem cells created in the lab by reprogramming adult cells from a patient’s own body can come under attack from the immune system, a new study in mice suggests.

The finding may present a major barrier to using reprogrammed stem cells, called induced pluripotent stem cells or iPS cells, in treatments to repair or replace damaged tissues.

The study introduces a needed note of caution into what had become a headlong race to rush reprogrammed cells into clinical use, says Chad Tang, a stem cell biologist at Stanford University who was not involved in the new work. “The iPS cell phenomenon is so new and so hyped up that it’s good we’re taking

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