Rat study suggests strategy for combating the munchies
Eating fatty foods may give you the munchies. A new study shows that when rats taste fat, it stimulates the same cellular buttons triggered by the active ingredient in marijuana, telling the body to keep on eating.
Uncovering the events that lead to this molecular “eat, eat” missive will make it easier to develop drugs that curb binge eating and other weight related-problems, says pharmacologist Daniele Piomelli, who led the new work.
Piomelli and his colleagues were interested in compounds known as endocannabinoids — the body’s version of the active ingredient in marijuana — and the role they play in overeating. Several kinds of endocannabinoids are released in the brain and body, but researchers are still discovering the nitty-gritty of where and when these compounds regulate mood and behavior.
So the researchers fed rats one of four liquid diets: fat (in the form of corn oil), protein, sugar or a nutrition shake comb