Synapse loss study points to new path for fighting degenerative brain disease
S. Hong et al/Science 2016
In the early stages of Alzheimer’s disease, an overzealous set of proteins and cells begins to chew away at the brain’s nerve cell connections, a study in mice suggests.
That finding, described March 31 in Science, adds to a growing body of research that implicates excessive synaptic pruning, a process that shapes the young brain by culling unused connections, with disorders later in life. The new work pins the loss of nerve cell–connecting synapses on particular immune system molecules and a notorious Alzheimer’s-linked protein.
By uniting these multiple strands of evidence, the study may help explain the earliest steps in Alzheimer’s march of neural destruction. “No one has put it together in quite this way,” says neuropathologist John Trojanowski. If the same process happens in humans, the new results may point to ways to slow or stop