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Human gene editing therapies are OK in certain cases, panel advises

Expert group recommends long-term tracking, other restrictions for germline tinkering

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4:38pm, February 14, 2017
bubble boy

EDITING OUT DISEASE  Gene therapy can cure a genetic disease called severe combined immunodeficiency, or “bubble boy,” disease. Using new gene editing techniques like CRISPR/Cas9 to treat genetic diseases is fine under certain conditions, but it should not be used to enhance people, a panel of experts says.

Human gene editing to prevent genetic diseases from being passed to future generations may be permissible under certain conditions, a panel of experts says.

Altering DNA in germline cells — embryos, eggs, and sperm, or cells that give rise to them — may be used to cure genetic diseases for future generations, provided it is done only to correct disease or disability, not to enhance people’s health or abilities, a report issued February 14 by the National Academies of Sciences and Medicine recommends. The decision contradicts earlier recommendations by organizers of a global summit on human gene editing, who concluded that gene editing with molecular scissors such as CRISPR/Cas9 should not be used to produce babies (SN: 12/26/15, p. 12).

Heritable gene

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