Long Live the Mammals: Antioxidant redirection extends mouse life span | Science News

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Long Live the Mammals: Antioxidant redirection extends mouse life span

11:00am, May 4, 2005

Cranking up the amount of antioxidants naturally produced in the body and directing those molecules to where they're needed can dramatically slow the aging process, according to a new study in mice. The finding adds credence to the controversial idea that antioxidants can extend life in people and other mammals.

Negatively charged molecular fragments generated by normal metabolism can damage cells and organs. Antioxidant molecules produced by cells or present in the diet can chemically neutralize those fragments, called free radicals, and stem the damage. One popular theory of aging dictates that with time, free radicals eventually overwhelm this natural defense, leading to various age-related declines.

Numerous studies in simple organisms, such as yeast, worms, and flies, have supported this theory by showing that enhancing production of natural antioxidants can extend life. However, evidence that antioxidants can slow the aging process in mammals has been less convinc

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