Vaccine stops deadly sand-fly-spread scourge in animal test

DNA immunization protects hamsters and mice from Leishmania parasite

By Nathan Seppa, 13:41 PM September 11, 2013

A lethal parasite appears susceptible to an experimental vaccine that seizes upon the scourge’s apparatus for invading cells.

Researchers prompted animals’ immune systems to destroy Leishmania protozoa by inducing mass-production of the very protein receptor that the parasites use as a pry bar to break into blood cells. Alerting the immune system to the receptor protein protects mice and hamsters against the parasites, the scientists report in the Sept. 11 Science Translational Medicine.


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