Alzheimer's disease protein structure may vary among patients

Two people with different symptoms had amyloid-beta fibers with different shapes

By Tina Hesman Saey, 10:28 AM September 12, 2013

Alzheimer’s disease proteins may contort differently in every patient.

In the brains of people with Alzheimer’s disease, a protein called amyloid-beta, or A-beta, forms fibers that congregate into plaques. A study now suggests that each person may have a distinct version of the fibers, which could affect how the disease develops.

Researchers led by Robert Tycko of the National Institutes of Health in Bethesda, Md., extracted A-beta from the brain tissue of two women who had died from Alzheimer’...

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