Girls may require more mutations than boys to develop autism

Girls may require more mutations than boys to develop autism

Result may help explain why more males wind up with disorder

By Laura Sanders, 11:00 AM February 27, 2014

Compared with males diagnosed with autism or other neurodevelopmental disorders, females with the disorders have more mutations in their DNA, scientists report in the March 6 American Journal of Human Genetics.  

In some still mysterious way, females may be better able to protect themselves against these mutations, some scientists think. That idea may help explain a striking difference: Four boys receive an autism diagnosis for every girl who does.

Small studies have hinted that girls can endur...

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