With Taxol, chromosomes divide and get conquered

With Taxol, chromosomes divide and get conquered

New mechanism discovered for decades-old cancer drug

By Tina Hesman Saey, 16:28 PM March 26, 2014

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A popular cancer drug has previously undiscovered tricks up its sleeve.

The best-selling chemotherapy drug paclitaxel (Taxol) treats breast, lung, ovarian and other cancers. Animal studies and experiments on human cells in lab dishes had suggested the drug worked by freezing cells in the act of dividing. But those studies used drug doses much higher than tumor cells in a patient’s body would encounter.

So Beth Weaver of the University of Wisconsin–Madison and colleagues measured d...

Source URL: https://www.sciencenews.org/article/taxol-chromosomes-divide-and-get-conquered