Placebo reins in pain in brain

By Bruce Bower, 15:53 PM April 15, 2008

Pain relief provided by a substance with no active ingredients, called a placebo, may have neural as well as psychological origins. Men who reported relief from a painful jaw after receiving a placebo injection also showed signs of enhanced activity of a brain substance that regulates stress and suppresses pain, say Jon-Kar Zubieta of the University of Michigan in Ann Arbor and his coworkers in the Aug. 24 Journal of Neuroscience.

The scientists administered an intravenous salt solution, whic...

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