Picking Pathways: Small molecule boosts morphine effect

By Aimee Cunningham, 15:54 PM April 15, 2008

Some small molecules affect specific pathways in one of the body's most common cell-regulating systems, according to a new report. The work could aid investigations of the pathways and lead to new drug therapies, the report's authors say.

When certain cell-surface receptors bind a chemical stimulus, such as an opiate or a hormone, they interact with so-called G proteins. These three-subunit proteins then separate into two parts, known as alpha and beta-gamma. Alan V. Smrcka of the University ...

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