Breast Cancer Lead: Overactive gene is linked to disease

By Patrick Barry, 15:57 PM April 15, 2008

Researchers have discovered a new breast cancer gene that's overly active in 30 to 40 percent of women with the disease. The high percentage makes the malfunctioning of this gene, called I-kappa-B kinase epsilon (IKBKE), one of the most widespread genetic traits among breast cancer patients, says William C. Hahn, coleader of the research team at the Broad Institute in Cambridge, Mass. Their study appears in the June 15 Cell.

Most cancer-related mutations are present in less than 10 percent of...

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