Protein links metabolism and circadian rhythms

Work could lead to drugs to combat obesity, aging and jetlag

By Tina Hesman Saey, 14:53 PM July 24, 2008

Cue stomach rumbles
Sirtuin 1 sets clock to

Timing is everything, especially when it comes to basic biological functions such as eating, sleeping and detoxifying. Scientists have known for ages that metabolism is tied to the body’s daily rhythms, but have not known how.

Now, two groups of researchers report in the July 25 Cell the discovery of a molecule that links metabolism to the circadian clock. The missing link turns out to be a protein called sirtuin 1 or SIRT1, whi...

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