Lupus not identical in twins

Pattern of chemical tags on DNA linked to the autoimmune disease

By Tina Hesman Saey, 18:32 PM December 21, 2009

Lupus can tell identical twins apart by the distinguishing marks the pairs carry on their DNA.

Fewer DNA methylation marks may leave one twin vulnerable to the inflammatory autoimmune disease, even while the other sibling remains healthy, a new study appearing online December 22 in Genome Research shows.

The finding suggests that environmental factors determine whether genetically susceptible twins will contract lupus, or systemic lupus erythematosus, which is characterized by the immu...

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