Why antipsychotics need time to kick in

Insight into how drugs work may explain the delayed action of medications for schizophrenia

By Laura Sanders, 15:23 PM June 6, 2012

New details about how some drugs for schizophrenia accumulate in the brain may help explain why patients often must wait for weeks for the medications to work.

Because many commonly used antipsychotics such as haloperidol and clozapine quickly latch onto their targets, it would seem that the drugs should bring fast relief.

“But there’s always a side story,” says neuroscientist Michael Cousin of the University of Edinburgh in Scotland. “There’s another layer of complexity.”

Researchers led...

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