First dengue vaccine trial disappoints

Shots protect against three virus subtypes, but not fourth

By Nathan Seppa, 11:51 AM September 12, 2012

The first large-scale test of a vaccine against dengue fever has failed to consistently prevent the viral disease in children, researchers report online September 11 in the Lancet. The mixed results have left scientists wondering how one form of the virus dodged what looked like a potent immunization regimen.

The shaky showing in Thai children won’t send scientists back to the drawing board, since the vaccine is already being tested extensively elsewhere. Officials at vaccine maker Sanofi P...

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