Nonstick trick in the brain

Coated particles can slip past brain’s barriers

By Sarah Zielinski, 11:55 AM September 21, 2012

Getting drugs into the brain has proved to be a nanoscale puzzle: Anything bigger than 64 nanometers — about the size of a small virus — gets stuck in the space between brain cells once it gets through the blood-brain barrier. Justin Hanes of Johns Hopkins University School of Medicine and colleagues got around this rule by coating particles destined for brain cells in a dense layer of a polymer called polyethylene glycol. PEG acts like a Teflon coating for the particles, preventing them from...

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