Research in cell communication system wins 2012 chemistry Nobel

G protein-coupled receptors crucial targets for drugs

By Tina Hesman Saey, 06:41 AM October 10, 2012

Robert Lefkowitz of Duke University in Durham, N.C., and Brian Kobilka of Stanford University will share the 2012 Nobel Prize in chemistry for work on molecules that help cells communicate with the outside world.

The molecules, called G-protein–coupled receptors, sit in a cell's outer membrane and identify hormones, odor molecules and other chemicals, transmitting that information to the inside of the cell.

"They are crucially positioned to regulate virtually every known physiological proc...

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