Drug breaks up Alzheimer’s-like deposits in mice

Drug breaks up Alzheimer’s-like deposits in mice

Failed human trials of similar approach fuel skepticism

By Laura Sanders, 12:30 PM December 6, 2012

A new therapy busts up deposits of sticky plaques associated with Alzheimer’s disease in the brains of mice. Further tests with the experimental drug could help settle the question of how important the plaques are to the disease, and might even lead to a treatment for its most advanced stages.

The study, described in the Dec. 6 Neuron, tested an antibody called mE8 in the brains of older mice that had been genetically altered to accumulate amyloid-beta, a protein that forms plaques in the ...

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