Hepatitis C drug goes after patients’ RNA

Compound targets genetic material that virus uses for replicating

By Nathan Seppa, 15:42 PM March 27, 2013

No matter what medications doctors throw at hepatitis C, it continues to defy treatment in some patients. But a new compound offers an approach quite apart from the rest: It assaults a kind of RNA that is implicated in allowing the virus to gain a foothold.

In most of a small group of patients who took the experimental drug, virus levels were knocked down, sometimes below the threshold of detection. The drug does this by targeting genetic material in the liver called microRNA-122. The hepa...

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