Mutation makes H5N1 flu lose its grip

Mutation makes H5N1 flu lose its grip

Laboratory-added genetic change makes avian influenza unable to bind to bird cells

By Tina Hesman Saey, 13:36 PM April 24, 2013

A mutation that helped make a laboratory version of the H5N1 bird flu transmissible through the air nearly obliterates the ability of the virus to latch onto avian cells. At the same time, the mutation slightly boosts the virus’s ability to infect human cells, an international team of researchers reports April 24 in Nature.

The finding follows up on controversial research published last year that transformed the H5N1 virus, a microbe usually restricted to birds, into one that could spread ...

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