Disorder at Work

Proteins without a definite shape can still take on important jobs

By Tanya Lewis, 13:07 PM January 24, 2013

Richard Kriwacki refused to give up on his protein. He had tried again and again to determine its three-dimensional shape, but in every experiment, the protein looked no more structured than a piece of cooked spaghetti.

Normally, this lack of form would be a sign that the protein had been destroyed, yet Kriwacki knew for a fact it could still do its job in controlling cell division. While discussing the conundrum with his adviser in the atrium of their La Jolla, Calif., lab, insight dawned:...

Source URL: https://www.sciencenews.org/article/disorder-work