Cancer variants found in ‘neglected’ region of genome

Mutations outside of genes associated with disease

By Tina Hesman Saey, 14:39 PM October 3, 2013

Parts of human DNA that do not contain genes but instead turn them on and off may be just as vulnerable to cancer-causing mutations as protein-producing genes are, a new study finds.

Using computer programs to comb through the DNA of 88 cancer patients, researchers identified 98 mutations in gene-regulating parts of the genome that may be causing the patients’ breast, prostate or brain tumors, the team reports in the Oct. 4 Science.

The findings may help researchers better understand which gene...

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