Reprogrammed stem cells may mirror embryonic ones after all

Donor genetics may explain why the two cell types vary

By Tina Hesman Saey, 09:32 AM October 28, 2013

BOSTON — Some concerns about whether reprogrammed stem cells are acceptable stand-ins for embryonic stem cells in biomedical research may be laid to rest by a new study.

Previously, scientists have found that gene activity, such as how genes turn on and off, differs between induced pluripotent stem cells, or iPS cells, and embryonic stem cells, the flexible cells that iPS cells are designed to mimic.

Those problems probably arise from the fact that iPS and embryonic stem cells come from donors ...

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