Protein may be target for Crohn's therapy

By Nathan Seppa, 15:48 PM April 15, 2008

A protein called MIF–short for macrophage migration inhibitory factor–plays a central role in the process of inflammation. Researchers now report that MIF's actions extend to the intestines. Their findings suggest that the protein perpetuates the chronic inflammation that characterizes Crohn's disease, a painful gut disorder.

In a series of experiments, the scientists induced mice to develop intestinal inflammation, or colitis. While not identical to Crohn's disease in people, this mouse ailm...

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