Huntington's Advance: Drug limits disease effects in laboratory mice

By Nathan Seppa, 15:49 PM April 15, 2008

A compound that inhibits enzymes that act as stop signs for genes counteracts the movement disorders brought on by Huntington's disease, a mouse study suggests.

In this hereditary disease, a genetic mutation results in oversized versions of the so-called huntingtin protein, portions of which stack up in the nuclei of brain cells. Patients develop impairments of thought, movement, and emotions for which there is no treatment or cure.

The mutant version of the huntingtin protein inhibits the act...

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