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James P. Allison of MD Anderson Cancer Center in Houston and Tasuku Honjo of Kyoto University in Japan have won the Nobel Prize in physiology or medicine for advances in harnessing the immune system to fight cancer.

All previous types of cancer therapy were directed at the tumor cell, but Allison’s and Honjo’s approach was to remove brakes that keep the immune system in check, unleashing...

Using gene editing, scientists have hoodwinked tumor cells into turning against their own kind.

Cancer cells circulating in the bloodstream have something of a homing instinct, able to find and return to the tumor where they originated. To capitalize on that ability, researchers engineered these roving tumor cells to secrete a protein that triggers a death switch in resident tumor cells...

This wasn’t 15-year-old Connor McMahon’s first time in the hospital. But the 107° fever he’d been running for three days had his dad frightened. The teen was hallucinating, talking gibberish and spouting curses.

“I thought he was going to die,” says Connor’s father, Don McMahon, who stayed close as his son received and recovered from an experimental treatment for leukemia. “It was really...

Few treatment options are available to people facing a second battle with a particularly fatal type of brain tumor called glioblastoma. But dosing the tumor with a genetically modified poliovirus — one that doesn’t cause the eponymous, devastating disease — may give these patients more time, a small clinical study suggests.

Of 61 people with recurring glioblastoma who were treated with...