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E.g., 12/14/2017
E.g., 12/14/2017
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  • CAR-T cells
  • breast cancer cells
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Your search has returned 109 articles:
  • Year in Review

    Approval of gene therapies for two blood cancers led to an ‘explosion of interest’ in 2017

    This year, gene therapy finally became a clinical reality. The U.S. Food and Drug Administration approved two personalized treatments that engineer a patient’s own immune system to hunt down and kill cancer cells. The treatments, the first gene therapies ever approved by the FDA, work in people with certain blood cancers, even patients whose cancers haven’t responded to other treatments.

    ...
    12/13/2017 - 08:27 Cancer, Immune Science
  • News in Brief

    When tumors fuse with blood vessels, clumps of breast cancer cells can spread

    PHILADELPHIA — If you want to beat them, join them. Some breast cancer tumors may follow that strategy to spread through the body.

    Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research. Cell biologist Vanesa Silvestri of Johns Hopkins...

    12/08/2017 - 11:42 Cancer, Cells
  • News in Brief

    Microbes hobble a widely used chemo drug

    Some bacteria may shield tumor cells against a common chemotherapy drug.

    Certain types of bacteria make an enzyme that inactivates the drug gemcitabine, researchers report in the Sept. 15 Science. Gemcitabine is used to treat patients with pancreatic, lung, breast and bladder cancers.

    Bacteria that produce the enzyme cytidine deaminase converted the drug to an inactive form. That...

    09/14/2017 - 14:00 Cancer, Microbiology
  • News

    Zika could one day help combat deadly brain cancer

    Zika’s damaging neurological effects might someday be enlisted for good — to treat brain cancer.

    In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone. Jeremy Rich, a regenerative medicine scientist at the University of California, San Diego, and colleagues report the findings...

    09/05/2017 - 16:54 Cancer, Biomedicine, Immune Science
  • Science Ticker

    FDA approves gene therapy to treat a rare cancer

    On August 30, the U.S. Food and Drug Administration approved a novel gene therapy for patients with a rare type of leukemia. This is the first time the agency has greenlighted a gene therapy approach for use in the United States.

    The treatment, called CAR-T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

    08/30/2017 - 17:17 Cancer, Genetics
  • News

    These bacteria may egg on colon cancer

    A bad bacterium may make colon cancer worse.

    Streptococcus gallolyticus spurred growth of some colon cancer cells in lab dishes and in mice, researchers report July 13 in PLOS Pathogens. S. gallolyticus stimulates a biochemical chain reaction that scientists already knew is involved in the development of colon cancer, the researchers discovered.

    Bacteria had to be in direct contact...

    07/13/2017 - 14:26 Microbiology, Cancer
  • News

    New kind of ‘tan in a bottle’ may one day protect against skin cancer

    A method that gives mice a tan without using ultraviolet radiation now works in human skin samples. It’s an early step in developing a lotion or cream that might provide fair-skinned folk with protection against skin cancer.

    As reported June 13 in Cell Reports, a topical drug penetrated and tanned laboratory samples of live human skin, absent the sun. Unlike self-tanning lotions that...

    06/13/2017 - 12:47 Health, Biomedicine, Cancer
  • News

    Therapy flags DNA typos to rev cancer-fighting T cells

    Mutations that prevent cells from spell-checking their DNA may make cancer cells vulnerable to immunotherapies, a new study suggests.

    A type of immune therapy known as PD-1 blockade controlled cancer in 77 percent of patients with defects in DNA mismatch repair — the system cells use to spell-check and fix errors in DNA (SN Online: 10/7/15). The therapy was effective against 12 different...

    06/09/2017 - 15:12 Cancer, Immune Science, Genetics, Biomedicine
  • News

    New test may improve pancreatic cancer diagnoses

    Pancreatic cancer is hard to detect early, when the disease is most amenable to treatment. But a new study describes a blood test that may aid the diagnosis of pancreatic cancer and someday make earlier screening feasible, the authors say.

    The test detects a combination of five tumor proteins that appear to be a reliable signature of the disease, the researchers report in the May 24...

    05/24/2017 - 17:50 Biomedicine, Cancer
  • Letters to the Editor

    Readers ponder the randomness of DNA errors

    At random

    As cells divide and grow, mutations may crop up in cancer-associated genes. A recent study found that more cancer mutations are caused by these random mistakes than other factors, such as environment or inheritance, Tina Hesman Saey reported in “DNA errors play big role in cancer” (SN: 4/15/17, p. 6).

    John Day wondered if replication errors are truly random, not just...

    05/17/2017 - 10:49 Cancer, Planetary Science