Medical innovations can be risky, as this issue’s cover story on new CAR-T cell therapies for cancer reveals. The treatments, which tailor a patient’s own immune system cells to attack cancer, can be astonishingly successful. But CAR-T therapy can also be an untamed beast, unleashing a ferocious immune response that indiscriminately attacks the body. The challenge scientists face now...06/27/2018 - 07:00 Health, Cancer, History of Science
Few treatment options are available to people facing a second battle with a particularly fatal type of brain tumor called glioblastoma. But dosing the tumor with a genetically modified poliovirus — one that doesn’t cause the eponymous, devastating disease — may give these patients more time, a small clinical study suggests.
Of 61 people with recurring glioblastoma who were treated with...
News in Brief
Colorectal cancer screening should begin at age 45 rather than 50, according to new guidelines released May 30 by the American Cancer Society. The recommendation is a response to the steady rise over decades in the colorectal cancer rate in younger Americans (SN: 4/1/17, p. 5).
For people at average risk for colorectal cancer — those without a personal or family history of the disease...
Starve the tumor, not the cell
Animal experiments demonstrate for the first time that transplanted tumors release a chemical into the host’s bloodstream that causes the host to produce blood vessels to supply the tumor.… If such a factor can be identified in human cancers … it might be possible to prevent the vascularization of tumors. Since tumors above a certain small size require...
Like a genetic handyman, an elusive enzyme deep inside certain cells repairs the tips of chromosomes, which fray as cells divide. It’s prized by rapidly dividing cells – like stem cells and tumor cells – and by scientists on the hunt for cancer and other disease therapies.
Now researchers have the best picture yet of this enzyme, called telomerase. Using cryo-electron microscopy,...