In the Dec. 9 SN: Lessons from the Pliocene, searching for new ways to fight MS, a supernova on repeat, the great gene drive debate, spider sleep secrets, an ailing boy gets new skin, kleptopredation and more.
PUMP IT UP A new type of CRISPR/Cas9-based gene therapy turned on muscle-building genes in mice that have muscular dystrophy. Muscle fibers (magenta) from mice that got the therapy (right) were bigger than fibers from untreated animals (left).
H.-K. Liao et al/Cell 2017
Evidence hierarchies, one version shown, classify types of studies according to the strength of evidence they provide. But a recent paper challenges the assumptions behind these hierarchies.
SKIN REPAIR A 7-year-old with a rare genetic condition lost most of the top layer of his skin, the epidermis. Scientists used a combination of stem cells and gene therapy to repair the damage.