NO GAIN Patients with an inherited form of blindness experienced temporary gains in vision after receiving gene therapy. But the retina of one person shows that nearly six years after the treatment, vision cells died in the treated area (outlined upper left corner; cooler colors signify cell death) and in the rest of the retina.
S.G. Jacobson et al/NEJM 2015
NUCLEAR DISARRAY Normally tightly packed bundles of DNA (as in the normal stem cells, left) come undone in cells that age prematurely (right), enlarging their nuclei and promoting aging.
Zhang et al/Science 2015; Reprinted with permission from AAAS
Researchers extracted and analyzed DNA from ancient mammoth remains, like this tusk found by a river on the Taimyr Peninsula in Siberia, and found evidence of isolation and inbreeding just prior to the animal’s extinction.