Immune Science

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patients behind mosquito bed nets

SWAT THAT VIRUS  Hospital patients recover from dengue virus infection under bed nets in Asunción, Paraguay, in 2012. The following year, the country hit a high of more than 144,500 reported cases. Vaccines may be the best means of defense against moquito-borne viruses like dengue, Zika and chikungunya.

sick child

UNEASY BREATHING  Some children have rare genetic variants that can turn their first encounter with colds and other respiratory viruses deadly.

Bacteroides fragilis and intestinal cells

MESSAGE RECEIVED  A microbe called Bacteroides fragilis (left image, boxed) sends out messages that calm the immune system, quelling inflammation in mouse intestinal cells (left, bottom half). These messages rest in pouches called outer membrane vesicles (yellow bubbles in reconstruction of microbe at right). Defective genes linked to Crohn’s disease might make it hard for people to get such messages.

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