Live Wires: Axons can influence nerve impulses

8:47am, September 5, 2007

The "wires" that carry electrical signals among nerve cells in the brain can influence the threshold at which the cells will send those signals, research on mouse-brain tissue shows.

The finding challenges the conventional view of nerve cells, or neurons. In that scenario, processes within a nerve cell determine whether or not to fire an electrical impulse, and the wire, called an axon, is a passive carrier of that signal.

"[Our research] says that the dogma is incorrect," says lead scientist Raju Metherate of the University of California, Irvine. A more active role for axons could be important for understanding how the brain processes sensory information. It could also have implications for the understanding of neurological diseases such as schizophrenia, Metherate says.

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