A new microneedle patch may help heart attack survivors recover | Science News

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A patch studded with tiny needles may help heart attack survivors recover

The bandage exudes proteins and other molecules that promote muscle cell growth

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2:03pm, November 28, 2018
illustration of microneedle patch

PATCHED UP  A new microneedle patch (illustrated in blue) that latches onto the surface of the heart could deliver therapeutic molecules to damaged tissue in heart attack survivors. 

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A new type of implantable bandage could help mend broken hearts.

Each bandage is a thin film that oozes a cocktail of molecules to heal tissue damaged during a heart attack. In experiments with rats and pigs, these patches helped minimize scarring and preserve the heart’s ability to pump blood, researchers report online November 28 in Science Advances. Such devices could someday curb heart attack survivors’ risk of heart failure.

The base of each heart-healing film is a polymer sheet studded with tiny needles — similar to other microneedle patches that deliver vaccines but designed to stick to a patient’s heart rather than her skin (SN: 8/5/17, p. 8). The surface of the polymer opposite the array of microneedles is coated in a gel containing cardiac stromal cells. These cells secrete molecules, such as proteins and tiny pieces of genetic material known as microRNAs, that support the growth of heart muscle cells.

“We’re treating [the patch cells] as little pharmacies,” says study coauthor Ke Cheng, a biological engineer at North Carolina State University in Raleigh. When a patch is attached to the heart, the microneedles funnel curative molecules from the cardiac stromal cells directly into the damaged tissue.

In rats, Cheng’s team tested how well the microneedle patches promoted healthy tissue growth and mitigated scarring. Three weeks after researchers induced rats to have heart attacks, the animals with microneedle patches had roughly 40 percent healthy tissue in the regions of their hearts affected by the heart attack, whereas as untreated rats had only about 10 percent.

a photo of heart tissue samples
For the pigs, the researchers tracked heart health by measuring how much blood was pumped from the animal’s left ventricle to the rest of its body with each heartbeat. Four hours after a heart attack, each heartbeat released about 56 to 57 percent of all the blood in the left ventricle, in both treated and untreated pigs. But 48 hours after the attack, the results began to diverge: Hearts treated with microneedle patches pumped about 60 percent of the left ventricle’s volume, while untreated hearts pumped about 50 percent. 

The new microneedle design “is a very interesting and exciting” idea, but researchers need to investigate how animals implanted with these patches fare over longer periods, says Tamer Mohamed, a cardiovascular researcher at the University of Louisville in Kentucky not involved in the work.

Before these microneedle patches are used to treat humans, Cheng’s team plans to swap out the polymer used in this study for a material that gradually dissolves inside the body. The researchers are also exploring less invasive ways to implant patches than open-heart surgery, Cheng says.

Citations

J. Tang et al. Cardiac cell–integrated microneedle patch for treating myocardial infarction. Science Advances. Published online November 28, 2018. doi: 10.1126/sciadv.aat9365.

Further Reading

A. Cunningham. Getting a flu ‘shot’ could soon be as easy as sticking on a Band-Aid. Science News. Vol. 192, August 5, 2017, p. 8.

M. Rosen. Bandage-like patch dissolves to deliver medicine to skin. Science News Online, August 2, 2013.

L. Beil. Reviving a tired heart. Science News. Vol. 180, October 22, 2011, p. 26.

T.H. Saey. Heart has cellular regeneration ability. Science News. Vol. 180, July 16, 2011, p. 9.

N. Seppa. Mining fat tissue for cardiac repair. Science News. Vol. 178, December 18, 2010, p. 15.

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