Why African striped mice can be the best of dads — or the worst

Flipping a molecular switch turns males from pup caregivers to pup killers

A male African striped mouse tends his pups

A male African striped mouse tends his pups. A gene called Agouti, which was previously known to play a role in the development of the mouse’s characteristic stripes, also turns out to be active in the part of the brain that regulates caretaking behavior.

C. Todd Reichart/Princeton University

The difference between a doting dad and a deadbeat one may come down to a molecular switch in the brain — at least in African striped mice.