Guard the bourbon fruitcake: Fruit flies like a little booze in their food. And once they get a nip, they’re hooked, say scientists studying Drosophila melanogaster, the darling of genetic scientists around the world. The flies show evidence of alcohol addiction, including drinking despite dangerous consequences, a study appearing online December 10 in Current Biology reports.
Studying a model of alcoholism in a simple organism like the fruit fly may lead to a better understanding of the disease in humans. The new research is “a big step forward,” says Zachary Rodd, a behavioral pharmacologist who studies rodent models of alcoholism at Indiana University School of Medicine in Indianapolis. “It’s always good to have many models. Each model has its benefits and its limitations. Drosophila has a lot of positives behind it.”
Earlier studies found that alcohol has profound physiological effects on fruit flies, but the new study is one of the first to offer flies the choice to drink. Anita Devineni and Ulrike Heberlein, both of the University of California, San Francisco, devised a fly-sized drinking device reminiscent of the water bottles in hamster cages. Flies held inside vials could sip from thin tubes holding either liquid food spiked with 15 percent ethanol or plain liquid food. The researchers measured the descent of the liquids inside each tube to get a readout of which food the flies preferred.