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Some GLP-1 drugs are more effective for those with specific gene variants

A large study of 23andMe customers found variants in two genes that play a role in weight loss, and nausea and vomiting

A woman wearing ankle-length black leggings stands barefoot on a scale. Her legs are visible below the knee only. Using GLP-1 drugs for obesity produces different results for people. Gene variants partly explain the drugs' efficacy and whether people will have side effects.

People taking GLP-1 drugs like Ozempic and Zepbound have varying levels of success with weight loss. A new study has uncovered variants in two genes that influence weight loss and side effects from the drugs.

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By Tina Hesman Saey

Some people’s genes influence how much weight they will lose and what side effects they will experience while taking GLP-1 drugs, such as Ozempic and Zepbound.