New mechanism discovered for decades-old cancer drug
Lauren M. Zasadil and B. A. Weaver
A popular cancer drug has previously undiscovered tricks up its sleeve.
The best-selling chemotherapy drug paclitaxel (Taxol) treats breast, lung, ovarian and other cancers. Animal studies and experiments on human cells in lab dishes had suggested the drug worked by freezing cells in the act of dividing. But those studies used drug doses much higher than tumor cells in a patient’s body would encounter.
So Beth Weaver of the University of Wisconsin–Madison and colleagues measured drug levels in breast tumors taken from women who had been treated with paclitaxel before surgery. Instead of stopping cell division, low, clinically relevant doses of the drug caused cells to pull their chromosomes in multiple directions, the researchers found. Cells caught in the multidirectional tug-of-war died after the split because their chromosomes had been scrambled, Weaver