New mechanism discovered for decades-old cancer drug
Lauren M. Zasadil and B. A. Weaver
A popular cancer drug has previously undiscovered tricks up its sleeve.
The best-selling chemotherapy drug paclitaxel (Taxol) treats breast, lung, ovarian and other cancers. Animal studies and experiments on human cells in lab dishes had suggested the drug worked by freezing cells in the act of dividing. But those studies used drug doses much higher than tumor cells in a patient’s body would encounter.