Cancer cells engineered with CRISPR slay their own kin | Science News

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Cancer cells engineered with CRISPR slay their own kin

The technique reduced the size of tumors, a study in mice finds

By
2:00pm, July 11, 2018
gene-edited cancer cells

ON THE OFFENSIVE  Gene-edited cancer cells (green) release a protein deadly to other tumor cells (red).

Using gene editing, scientists have hoodwinked tumor cells into turning against their own kind.

Cancer cells circulating in the bloodstream have something of a homing instinct, able to find and return to the tumor where they originated. To capitalize on that ability, researchers engineered these roving tumor cells to secrete a protein that triggers a death switch in resident tumor cells they encounter. The cancer-fighting cancer cells also have a built-in suicide switch — so the weaponized cells self-destruct before they can start tumors of their own, the team reports in the July 11 Science Translational Medicine.

The new study isn’t the first attempt to fight cancer with cancer. Previous research has used circulating tumor cells to deliver cancer-killing viruses to noncirculating tumor cells, for example. But the new approach uses a gene-editing technology called CRISPR

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