E. coli toxin shows its deadly touch

In 1993, Escherichia coli, a normally harmless bacterium, drew national headlines when it sickened and killed people who ate undercooked hamburgers from a Seattle fast-food joint.

Unlike most E. coli, the strain at fault, known as O157:H7, produces two chemicals called verotoxins that destroy cells in the intestines and kidneys.

In the July 15 Genes & Development, researchers in Japan report that verotoxin II binds to a protein whose usual role is to prevent cells from committing suicide.