A master regulator of gene activity sets skin cells to make melanin every 48 hours
Sunbathing — if you must do it — should be limited to every other day, a new study suggests. You’ll get darker and prevent some skin damage.
That’s because skin makes the protective pigment melanin only every 48 hours, researchers report October 25 in Molecular Cell. Daily sunbathing can disrupt the pigment’s production and leave skin vulnerable to damage from ultraviolet light.
A protein called MITF coordinates skin-darkening melanin production with other skin protection mechanisms in response to UV light, molecular geneticist Carmit Levy of Tel Aviv University and her colleagues discovered. The team shone UV-B light on mice every 24, 48 or 72 hours for 60 days. Mice exposed to UV-B radiation on the 48-hour schedule developed darker skin and had less DNA damage than mice in the other groups. Mouse and human skin cells grown in lab dishes that were exposed to UV light every other day also made more melanin than cells that were irradiated daily.
Other experiments with skin cells in dishes suggest that within minutes of UV exposure, MITF turns on genes involved in skin cell survival. Those genes make proteins engaged in inflammation, DNA repair and recruitment of immune cells to the skin. Only later does MITF give the OK for melanin production to begin. Hitting cells with daily UV interrupts melanin production, leaving skin without its protective shield, the researchers found.
H. Malcov-Brog et al. UV-protection timer controls linkage between stress and pigmentation skin protection systems. Molecular Cell. Vol. 72, October 25, 2018. doi: 10.1016/j.molcel.2018.09.022.
A. Cunningham. New kind of ‘tan in a bottle’ may one day protect against skin cancer. Science News. Vol. 191, July 8, 2017, p. 11.
N. Seppa. UV Blocker: Lotion yields protective tan in fair-skinned mice. Science News. Vol. 170, September 23, 2006, p. 196.