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Autoantibodies are a type of antibody that mistakenly target a person’s own proteins. One such internal attack comes from autoantibodies that take aim at part of the AMPA receptor, a protein that sits on the outside of nerve cells and detects incoming chemical messages. These autoantibodies interfere with the receptor’s message-sensing job, neurologist Christian Geis of Jena University Hospital in Germany and colleagues found.
The team purified autoantibodies from patients suffering from autoimmune encephalitis, a brain inflammation disease that causes confusion, seizures and memory trouble. When the researchers put these human autoantibodies into the brains of mice, the animals began showing memory problems, too. After the autoantibodies were infused into the mice’s cerebrospinal fluid or injected directly into the brain, the animals were worse at recognizing new objects placed in their cage than mice that didn’t receive the antibodies.
These mice also showed signs of anxiety, spending less time in wide open parts of a maze than mice that hadn’t received the human autoantibodies and preferring to hunker down in covered areas.
Experiments on mice and human cells in dishes revealed the nature of the brain attack. Autoantibodies attached to particular bits of AMPA receptors and then forced those bits to move inside nerve cells where they were no longer effective, Geis and colleagues found. This shift left the nerve cells worse at sensing chemical signals from other nerve cells, a deficit that might have caused the mice’s memory problems.
The details of this autoantibody brain attack might point out ways to help nerve cells under siege maintain communication, Geis says. Current treatments for autoimmune encephalitis are less specific, involving the removal of harmful antibodies from the blood or tamping down a person’s immune response.
Autoantibodies have been linked to a variety of other illnesses including lupus, autism and schizophrenia. But some of those results are difficult to interpret, Geis cautions. For instance, although studies have turned up autoantibodies in the blood of people with schizophrenia, some scientists have questioned how reliable those measurements are. What’s more, similar autoantibodies have been found in healthy people, results that leaves autoantibodies’ roles in schizophrenia and some other diseases murky.