Bacterial toxin may lead to less painful treatments for diabetes and brain cancer
Take the nasty bacterium that causes cholera, delete the gene for its well-studied toxin, and you should end up with a harmless microbe that can immunize people against the real thing. It sounded like a good plan, recalls Alessio Fasano of the University of Maryland School of Medicine in Baltimore.
The scheme failed, however. A decade ago, when Fasano and his colleagues used a genetically stripped